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The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols PDF Author: Warren H. Finlay
Publisher: Academic Press
ISBN: 9780122569715
Category : Medical
Languages : en
Pages : 328

Book Description
The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models. The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols. This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols PDF Author: Warren H. Finlay
Publisher: Academic Press
ISBN: 9780122569715
Category : Medical
Languages : en
Pages : 328

Book Description
The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models. The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols. This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols PDF Author: Warren H. Finlay
Publisher: Academic Press
ISBN: 0081027869
Category : Technology & Engineering
Languages : en
Pages : 302

Book Description
The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Pharmaceutical Inhalation Aerosol Technology, Third Edition PDF Author: Anthony J. Hickey
Publisher: CRC Press
ISBN: 0429619561
Category : Medical
Languages : en
Pages : 784

Book Description
This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors

Evolving in Vitro and in Silico Methods for Predicting Performance in Respiratory Drug Delivery Applications

Evolving in Vitro and in Silico Methods for Predicting Performance in Respiratory Drug Delivery Applications PDF Author: Conor Aidan Ruzycki
Publisher:
ISBN:
Category : Aerosol therapy
Languages : en
Pages : 0

Book Description
The overarching theme of this work is the investigation and development of in vitro and in silico methods used to characterize inhaled pharmaceutical aerosols. The ultimate aim is to expand and strengthen the links between applied science and clinical practice for inhaled medications. Chapter 1 introduces the structure of the thesis. Chapter 2 consists of a review of literature. Relevant metrics used in the characterization of inhaled therapies are discussed, together with advanced in vitro and in silico methods for characterizing respiratory tract deposition and drug disposition. Chapter 3 describes an in vitro study on deposition from commercially available pharmaceutical inhalers in the Alberta Idealized Throat. This mouth-throat geometry has been used to accurately characterize aerosol deposition in terms of extrathoracic and total lung doses, though its ability to replicate in vivo deposition from some inhalers requires careful consideration of the underlying aerosol mechanics. We hypothesized that differences between in vitro and in vivo data may be partly caused by variations in factors not typically considered during in vitro testing, primarily the insertion angle of the inhaler into the mouth-throat geometry itself. Three of six examined inhalers showed sensitivity to the angle of insertion. For DPIs, this sensitivity may be reduced using larger diameter mouthpieces and smaller particle sizes in powder formulations. For pMDIs, lower momentum sprays demonstrated more consistent performance. Consideration of these factors in future devices and formulations may improve the consistency of dosing during real-world use. Chapter 4 describes a combined in vitro - in silico methodology to predict systemic exposure of budesonide from dry powder inhalers, incorporating in vitro measurements of intrathoracic particle size distributions, regional lung deposition modeling, and pharmacokinetics. Good agreement between predictions and in vivo data were obtained without the requirement of extraneous fit factors, suggesting the model is robust for well-characterized therapeutic agents like budesonide. Comparatively modest deposition in the small conducting airways was predicted to occur with each dry powder inhaler despite large in vitro differences in performance. Tracheobronchial deposition was predicted to correlate poorly with systemic drug concentrations, suggesting that overt reliance on systemic exposure data in establishing bioequivalence of locally acting inhaled therapies may not properly elucidate differences between formulations. Rather, a combination of methods like that proposed in the present work may aid in better predicting bioequivalence. In Chapter 5, a novel in vitro - in silico methodology was developed to characterize nebulizer performance in the context of methacholine challenge testing. The incorporation of experimental methods with hygroscopic theory and lung deposition modeling allowed for the quantification of regional deposition of methacholine and better estimation of the provocative dose than is provided by existing methods, which likely overestimate the relevant dose by considerable and device-dependent margins. Measurements of airstream conditions suggested that droplets exiting nebulizer mouthpieces exist in highly concentrated states compared to stock solutions, and upon inhalation these droplets can be expected to undergo significant hygroscopic growth. The procedure outlined in Chapter 5 may serve as step towards standardizing the determination of provocative doses obtained with methacholine challenge testing, which could improve the translatability of results currently obtained with disparate methods and protocols. Finally, Chapter 6 summarizes major conclusions, identifies contributions to knowledge, and proposes potential avenues for future work. Methods described in this thesis provide a framework for improving upon the standard pharmacopeial methods used to characterize pharmaceutical aerosols. With increased focus on the use of inhaled aerosols as a vehicle for both local and systemic delivery of medication, such methods are of interest in streamlining the drug development process and in optimizing future devices and formulations.

Proceedings of the 7th Biennial Conference on Engineering Systems Design and Analysis--2004

Proceedings of the 7th Biennial Conference on Engineering Systems Design and Analysis--2004 PDF Author:
Publisher: Amer Society of Mechanical
ISBN:
Category : Technology & Engineering
Languages : en
Pages : 750

Book Description


Atomization and Sprays

Atomization and Sprays PDF Author:
Publisher:
ISBN:
Category : Atomization
Languages : en
Pages : 642

Book Description


Journal de la Société Royale D'astronomie Du Canada

Journal de la Société Royale D'astronomie Du Canada PDF Author: Royal Astronomical Society of Canada
Publisher:
ISBN:
Category : Astronomy
Languages : en
Pages :

Book Description
"Library catalogue in 1911" (31 p.) appended to v. 4.

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives PDF Author: Anthony J. Hickey
Publisher: Elsevier
ISBN: 0128123362
Category : Science
Languages : en
Pages : 110

Book Description
Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

New Research Centers

New Research Centers PDF Author:
Publisher:
ISBN:
Category : Learned institutions and societies
Languages : en
Pages : 416

Book Description


International Research Centers Directory

International Research Centers Directory PDF Author:
Publisher:
ISBN:
Category : Research institutes
Languages : en
Pages : 730

Book Description